The gene related to anergy in lymphocytes, an E3 ubiquitin ligase, is necessary for anergy induction in CD4 T cells.
Identifieur interne : 001650 ( Main/Exploration ); précédent : 001649; suivant : 001651The gene related to anergy in lymphocytes, an E3 ubiquitin ligase, is necessary for anergy induction in CD4 T cells.
Auteurs : Christine M. Seroogy [États-Unis] ; Luis Soares ; Erik A. Ranheim ; Leon Su ; Claire Holness ; Debra Bloom ; C Garrison FathmanSource :
- Journal of immunology (Baltimore, Md. : 1950) [ 0022-1767 ] ; 2004.
Descripteurs français
- KwdFr :
- MESH :
- biosynthèse : Interleukine-2.
- immunologie : Lymphocytes T CD4+.
- physiologie : Ubiquitin-protein ligases.
- Animaux, Phénotype, Souris, Souris de lignée BALB C, Tolérance immunitaire.
English descriptors
- KwdEn :
- MESH :
- chemical , biosynthesis : Interleukin-2.
- immunology : CD4-Positive T-Lymphocytes.
- chemical , physiology : Ubiquitin-Protein Ligases.
- Animals, Immune Tolerance, Mice, Mice, Inbred BALB C, Phenotype.
Abstract
Acquisition of the anergy phenotype in T cells is blocked by inhibitors of protein synthesis and calcineurin activity, suggesting that anergic T cells may have a unique genetic program. Retroviral transduction of hemopoietic stem cells from TCR transgenic mice and subsequent reconstitution of syngeneic mice to express the E3 ubiquitin ligase, gene related to anergy in lymphocytes (GRAIL), or an enzymatically inactive form, H2N2 GRAIL, allowed analysis of the role of GRAIL in T cell anergy in vivo. Constitutive expression of GRAIL was sufficient to render naive CD4 T cells anergic, however, when the enzymatically inactive form H2N2 GRAIL was expressed, it functioned as a dominant negative of endogenous GRAIL and blocked the development of anergy. These data provide direct evidence that a biochemical pathway composed of GRAIL and/or GRAIL-interacting proteins is important in the development of the CD4 T cell anergic phenotype in vivo.
DOI: 10.4049/jimmunol.173.1.79
PubMed: 15210761
Affiliations:
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Seroogy</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA. cmseroogy@wisc.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305</wicri:regionArea><wicri:noRegion>CA 94305</wicri:noRegion></affiliation></author><author><name sortKey="Soares, Luis" sort="Soares, Luis" uniqKey="Soares L" first="Luis" last="Soares">Luis Soares</name></author><author><name sortKey="Ranheim, Erik A" sort="Ranheim, Erik A" uniqKey="Ranheim E" first="Erik A" last="Ranheim">Erik A. Ranheim</name></author><author><name sortKey="Su, Leon" sort="Su, Leon" uniqKey="Su L" first="Leon" last="Su">Leon Su</name></author><author><name sortKey="Holness, Claire" sort="Holness, Claire" uniqKey="Holness C" first="Claire" last="Holness">Claire Holness</name></author><author><name sortKey="Bloom, Debra" sort="Bloom, Debra" uniqKey="Bloom D" first="Debra" last="Bloom">Debra Bloom</name></author><author><name sortKey="Fathman, C Garrison" sort="Fathman, C Garrison" uniqKey="Fathman C" first="C Garrison" last="Fathman">C Garrison Fathman</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15210761</idno><idno type="pmid">15210761</idno><idno type="doi">10.4049/jimmunol.173.1.79</idno><idno type="wicri:Area/PubMed/Corpus">000330</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000330</idno><idno type="wicri:Area/PubMed/Curation">000330</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000330</idno><idno type="wicri:Area/PubMed/Checkpoint">000296</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000296</idno><idno type="wicri:Area/Ncbi/Merge">000101</idno><idno type="wicri:Area/Ncbi/Curation">000101</idno><idno type="wicri:Area/Ncbi/Checkpoint">000101</idno><idno type="wicri:doubleKey">0022-1767:2004:Seroogy C:the:gene:related</idno><idno type="wicri:Area/Main/Merge">001680</idno><idno type="wicri:Area/Main/Curation">001650</idno><idno type="wicri:Area/Main/Exploration">001650</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The gene related to anergy in lymphocytes, an E3 ubiquitin ligase, is necessary for anergy induction in CD4 T cells.</title><author><name sortKey="Seroogy, Christine M" sort="Seroogy, Christine M" uniqKey="Seroogy C" first="Christine M" last="Seroogy">Christine M. Seroogy</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA. cmseroogy@wisc.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305</wicri:regionArea><wicri:noRegion>CA 94305</wicri:noRegion></affiliation></author><author><name sortKey="Soares, Luis" sort="Soares, Luis" uniqKey="Soares L" first="Luis" last="Soares">Luis Soares</name></author><author><name sortKey="Ranheim, Erik A" sort="Ranheim, Erik A" uniqKey="Ranheim E" first="Erik A" last="Ranheim">Erik A. Ranheim</name></author><author><name sortKey="Su, Leon" sort="Su, Leon" uniqKey="Su L" first="Leon" last="Su">Leon Su</name></author><author><name sortKey="Holness, Claire" sort="Holness, Claire" uniqKey="Holness C" first="Claire" last="Holness">Claire Holness</name></author><author><name sortKey="Bloom, Debra" sort="Bloom, Debra" uniqKey="Bloom D" first="Debra" last="Bloom">Debra Bloom</name></author><author><name sortKey="Fathman, C Garrison" sort="Fathman, C Garrison" uniqKey="Fathman C" first="C Garrison" last="Fathman">C Garrison Fathman</name></author></analytic><series><title level="j">Journal of immunology (Baltimore, Md. : 1950)</title><idno type="ISSN">0022-1767</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>CD4-Positive T-Lymphocytes (immunology)</term><term>Immune Tolerance</term><term>Interleukin-2 (biosynthesis)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Phenotype</term><term>Ubiquitin-Protein Ligases (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Interleukine-2 (biosynthèse)</term><term>Lymphocytes T CD4+ (immunologie)</term><term>Phénotype</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Tolérance immunitaire</term><term>Ubiquitin-protein ligases (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Interleukin-2</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Interleukine-2</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Lymphocytes T CD4+</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Ubiquitin-protein ligases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Ubiquitin-Protein Ligases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Immune Tolerance</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Phenotype</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Phénotype</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Tolérance immunitaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Acquisition of the anergy phenotype in T cells is blocked by inhibitors of protein synthesis and calcineurin activity, suggesting that anergic T cells may have a unique genetic program. Retroviral transduction of hemopoietic stem cells from TCR transgenic mice and subsequent reconstitution of syngeneic mice to express the E3 ubiquitin ligase, gene related to anergy in lymphocytes (GRAIL), or an enzymatically inactive form, H2N2 GRAIL, allowed analysis of the role of GRAIL in T cell anergy in vivo. Constitutive expression of GRAIL was sufficient to render naive CD4 T cells anergic, however, when the enzymatically inactive form H2N2 GRAIL was expressed, it functioned as a dominant negative of endogenous GRAIL and blocked the development of anergy. These data provide direct evidence that a biochemical pathway composed of GRAIL and/or GRAIL-interacting proteins is important in the development of the CD4 T cell anergic phenotype in vivo.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Bloom, Debra" sort="Bloom, Debra" uniqKey="Bloom D" first="Debra" last="Bloom">Debra Bloom</name><name sortKey="Fathman, C Garrison" sort="Fathman, C Garrison" uniqKey="Fathman C" first="C Garrison" last="Fathman">C Garrison Fathman</name><name sortKey="Holness, Claire" sort="Holness, Claire" uniqKey="Holness C" first="Claire" last="Holness">Claire Holness</name><name sortKey="Ranheim, Erik A" sort="Ranheim, Erik A" uniqKey="Ranheim E" first="Erik A" last="Ranheim">Erik A. Ranheim</name><name sortKey="Soares, Luis" sort="Soares, Luis" uniqKey="Soares L" first="Luis" last="Soares">Luis Soares</name><name sortKey="Su, Leon" sort="Su, Leon" uniqKey="Su L" first="Leon" last="Su">Leon Su</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Seroogy, Christine M" sort="Seroogy, Christine M" uniqKey="Seroogy C" first="Christine M" last="Seroogy">Christine M. Seroogy</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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